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Beta-Transducin Repeat Containing Protein (bTRCP)

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FBW1A; FBXW1A; FWD1; bTrC; bTrCP1; F-box/WD Repeat-Containing 1A; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor

Beta-Transducin Repeat Containing Protein (bTRCP)
CCC C251
HGNC 1144
MGI 1338871
PubMed 22976441
UniProt Q9Y297
Wiki BTRC

F-box/WD repeat-containing protein 1A is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-Transducin Repeat Containing Protein (bTRCP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-Transducin Repeat Containing Protein (bTRCP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-Transducin Repeat Containing Protein (bTRCP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-Transducin Repeat Containing Protein (bTRCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-Transducin Repeat Containing Protein (bTRCP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-Transducin Repeat Containing Protein (bTRCP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-Transducin Repeat Containing Protein (bTRCP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-Transducin Repeat Containing Protein (bTRCP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-Transducin Repeat Containing Protein (bTRCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-Transducin Repeat Containing Protein (bTRCP) ELISA Kit Customized Service Offer
  1. "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase."Nature 396:590-594(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif."Mol. Cell 1:565-574(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2."Biochem. Biophys. Res. Commun. 256:127-132(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1."J. Biol. Chem. 274:28169-28174(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The SCF(beta-TRCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I-kappa-B-alpha and beta-catenin and stimulates I-kappa-B-alpha ubiquitination in vitro."Genes Dev. 13:270-283(1999) [PubMed] [Europe PMC] [Abstract]
  11. "SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase."EMBO J. 19:2580-2591(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination."J. Biol. Chem. 275:2877-2884(2000) [PubMed] [Europe PMC] [Abstract]
  13. "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome."Mol. Cell 6:409-419(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins."Mol. Biol. Cell 12:1431-1443(2001) [PubMed] [Europe PMC] [Abstract]
  15. "ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase."Mol. Cell. Biol. 21:2192-2202(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100."J. Biol. Chem. 277:22111-22114(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells."J. Cell Sci. 115:2771-2780(2002) [PubMed] [Europe PMC] [Abstract]
  18. "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation."Oncogene 21:3978-3987(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase."Dev. Cell 4:813-826(2003) [PubMed] [Europe PMC] [Abstract]
  20. "SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase."Genes Dev. 17:3062-3074(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor."J. Biol. Chem. 278:42477-42486(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage."Nature 426:87-91(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1."J. Biol. Chem. 279:14484-14487(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition."Nat. Cell Biol. 6:931-940(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Wnt-dependent regulation of the E-cadherin repressor snail."J. Biol. Chem. 280:11740-11748(2005) [PubMed] [Europe PMC] [Abstract]
  26. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
  27. "DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases."Genes Dev. 20:2949-2954(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP."Mol. Cell. Biol. 26:4316-4326(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing."Proc. Natl. Acad. Sci. U.S.A. 103:33-38(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells."Mol. Cancer Res. 8:119-130(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase."Mol. Cell 11:1445-1456(2003) [PubMed] [Europe PMC] [Abstract]
  32. "Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination."Cell 129:1165-1176(2007) [PubMed] [Europe PMC] [Abstract]