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Ubiquitin Specific Peptidase 7 (USP7)

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HAUSP; TEF1; Ubiquitin Carboxyl-Terminal Hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7; Ubiquitin-specific-processing protease 7

Ubiquitin Specific Peptidase 7 (USP7)
CCC C255
HGNC 12630
MGI 2182061
PubMed 23603909
RGD 1306915
UniProt Q93009
Wiki USP7

HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC255Hu01 Recombinant Ubiquitin Specific Peptidase 7 (USP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC255Hu01 Polyclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) WB; IHC; ICC; IP.
Assay Kits SEC255Hu ELISA Kit for Ubiquitin Specific Peptidase 7 (USP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 7 (USP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 7 (USP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 7 (USP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 7 (USP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 7 (USP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 7 (USP7) ELISA Kit Customized Service Offer
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  2. ErratumEMBO J. 16:1519-1530(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product."Mol. Cell. Neurosci. 20:298-306(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."Nature 416:648-653(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP."J. Biol. Chem. 278:47753-47761(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A dynamic role of HAUSP in the p53-Mdm2 pathway."Mol. Cell 13:879-886(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7."J. Virol. 79:12342-12354(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Critical role for Daxx in regulating Mdm2."Nat. Cell Biol. 8:855-862(2006) [PubMed] [Europe PMC] [Abstract]
  11. "FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP."Nat. Cell Biol. 8:1064-1073(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization."FEBS J. 274:4256-4270(2007) [PubMed] [Europe PMC] [Abstract]
  13. "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex."EMBO J. 27:1863-1874(2008) [PubMed] [Europe PMC] [Abstract]
  14. "AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive p53 turnover."Mol. Biol. Cell 19:5029-5029(2008) [PubMed] [Europe PMC] [Abstract]
  15. "The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network."Nature 455:813-817(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0."Virus Res. 137:64-71(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Daxx is reciprocally regulated by Mdm2 and Hausp."Biochem. Biophys. Res. Commun. 393:542-545(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "TSPYL5 suppresses p53 levels and function by physical interaction with USP7."Nat. Cell Biol. 13:102-108(2011) [PubMed] [Europe PMC] [Abstract]
  24. "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1."Nucleic Acids Res. 39:8355-8365(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability."Proc. Natl. Acad. Sci. U.S.A. 109:4828-4833(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes."ChemBioChem 13:1416-1420(2012) [PubMed] [Europe PMC] [Abstract]
  28. "The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation."EMBO J. 31:3596-3606(2012) [PubMed] [Europe PMC] [Abstract]
  29. "UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair."Nat. Genet. 44:598-602(2012) [PubMed] [Europe PMC] [Abstract]
  30. "Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair."Nat. Genet. 44:593-597(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity."Immunity 39:259-271(2013) [PubMed] [Europe PMC] [Abstract]
  32. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  33. "The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin."Mol. Cell. Biol. 34:4355-4366(2014) [PubMed] [Europe PMC] [Abstract]
  34. "Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde."Cell 111:1041-1054(2002) [PubMed] [Europe PMC] [Abstract]
  35. "Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization."Mol. Cell 18:25-36(2005) [PubMed] [Europe PMC] [Abstract]
  36. "Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway."PLoS Biol. 4:228-239(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Molecular recognition of p53 and MDM2 by USP7/HAUSP."Nat. Struct. Mol. Biol. 13:285-291(2006) [PubMed] [Europe PMC] [Abstract]