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Death Associated Protein 6 (DAP6)

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DAXX; BING2; EAP1; ETS1-associated protein 1; Fas death domain-associated protein

Death Associated Protein 6 (DAP6)
CCC C259
HGNC 2681
MGI 1197015
PubMed 9111295
RGD 621227
UniProt Q9UER7
Wiki DAP6

DAXX ,a Death-Domain-Associated Protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. It has been associated heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation.DAXX is almost uniformally expressed throughout the body, except the testes and thymus have higher expression of the protein. At the level of the cell, DAXX is found as well in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as in the nucleus where it is interacting with some subnuclear structures. A lot of other interacting molecules are known, but not always, there is an understanding of the specific function and relevance of this interaction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC259Hu01 Recombinant Death Associated Protein 6 (DAP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Death Associated Protein 6 (DAP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 6 (DAP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein 6 (DAP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein 6 (DAP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Associated Protein 6 (DAP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Associated Protein 6 (DAP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 6 (DAP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein 6 (DAP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein 6 (DAP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Associated Protein 6 (DAP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Associated Protein 6 (DAP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Associated Protein 6 (DAP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Associated Protein 6 (DAP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Associated Protein 6 (DAP6) ELISA Kit Customized Service Offer
  1. "Daxx, a novel Fas-binding protein that activates JNK and apoptosis."Cell 89:1067-1076(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region."DNA Cell Biol. 16:1289-1298(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death."J. Cell Sci. 111:2029-2041(1998) [PubMed] [Europe PMC] [Abstract]
  4. "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
  5. "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes."Oncogene 19:745-753(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx."J. Biol. Chem. 286:19576-19588(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx."EMBO J. 18:3702-3711(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis."J. Exp. Med. 191:631-640(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML."Mol. Cell. Biol. 20:1784-1796(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of Daxx-mediated apoptosis by heat shock protein 27."Mol. Cell. Biol. 20:7602-7612(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm."J. Biol. Chem. 276:39103-39106(2001) [PubMed] [Europe PMC] [Abstract]
  15. "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation."Nat. Cell Biol. 3:708-714(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Modification of Daxx by small ubiquitin-related modifier-1."Biochem. Biophys. Res. Commun. 295:495-500(2002) [PubMed] [Europe PMC] [Abstract]
  17. "The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1."J. Biol. Chem. 277:19783-19791(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration."J. Biol. Chem. 277:25446-25456(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek."J. Cell Sci. 115:3319-3330(2002) [PubMed] [Europe PMC] [Abstract]
  20. "HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells."Cancer Res. 63:8271-8277(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization."J. Biol. Chem. 278:47245-47252(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity."Mol. Cell. Biol. 23:950-960(2003) [PubMed] [Europe PMC] [Abstract]
  23. "The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies."Proc. Natl. Acad. Sci. U.S.A. 100:10635-10640(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP."Biochem. Biophys. Res. Commun. 320:760-765(2004) [PubMed] [Europe PMC] [Abstract]
  25. "A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein."J. Biol. Chem. 279:20369-20377(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Negative regulation of p53 functions by Daxx and the involvement of MDM2."J. Biol. Chem. 279:50566-50579(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  28. "BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase."J. Biol. Chem. 281:12664-12672(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors."Mol. Cell 24:341-354(2006) [PubMed] [Europe PMC] [Abstract]
  30. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Critical role for Daxx in regulating Mdm2."Nat. Cell Biol. 8:855-862(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death."Cancer Res. 67:66-74(2007) [PubMed] [Europe PMC] [Abstract]
  33. "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex."EMBO J. 27:1863-1874(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection."J. Virol. 82:126-137(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection."J. Virol. 82:12543-12554(2008) [PubMed] [Europe PMC] [Abstract]
  37. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  40. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Daxx is reciprocally regulated by Mdm2 and Hausp."Biochem. Biophys. Res. Commun. 393:542-545(2010) [PubMed] [Europe PMC] [Abstract]
  42. "The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3."Genes Dev. 24:1253-1265(2010) [PubMed] [Europe PMC] [Abstract]
  43. "Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection."J. Virol. 84:7185-7194(2010) [PubMed] [Europe PMC] [Abstract]
  44. "Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres."Proc. Natl. Acad. Sci. U.S.A. 107:14075-14080(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  46. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  47. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  48. "DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin."Genome Res. 23:440-451(2013) [PubMed] [Europe PMC] [Abstract]
  49. "Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization."Cell Cycle 13:249-267(2014) [PubMed] [Europe PMC] [Abstract]
  50. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  51. "Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection."J. Virol. 88:14350-14363(2014) [PubMed] [Europe PMC] [Abstract]
  52. "Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX."Mol. Cell 53:631-644(2014) [PubMed] [Europe PMC] [Abstract]
  53. "Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C."Structure 18:1642-1653(2010) [PubMed] [Europe PMC] [Abstract]
  54. "NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx."Biomol. NMR. Assign. 5:75-77(2011) [PubMed] [Europe PMC] [Abstract]
  55. "Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX."Nat. Struct. Mol. Biol. 19:1287-1292(2012) [PubMed] [Europe PMC] [Abstract]
  56. "DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition."Nature 491:560-565(2012) [PubMed] [Europe PMC] [Abstract]