Fusion (FUS)
[Edit]ALS6; TLS; hnRNP-P2; Amyotrophic Lateral Sclerosis 6; Heterogeneous Nuclear Ribonucleoprotein P2; 75 kDa DNA-pairing protein; Translocated in liposarcoma protein; CHOP
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FUS is a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding. In addition recognition sites for the transcription factors AP2, GCF, Sp1 have been identified in FUS.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC260Hu01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC260Hu01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| MAC260Hu22 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC260Hu | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC260Mu01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC260Mu02 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC260Mu01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| LAC260Mu81 | FITC-Linked Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| LAC260Mu71 | Biotin-Linked Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC. | |
| PAC260Mu02 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC260Mu | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC260Ra01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Fusion (FUS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Fusion (FUS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Fusion (FUS) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Fusion (FUS) | ELISA Kit Customized Service Offer |
- "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."Nature 363:640-644(1993) [PubMed] [Europe PMC] [Abstract]
- "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."Nat. Genet. 4:175-180(1993) [PubMed] [Europe PMC] [Abstract]
- "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes."Gene 221:191-198(1998) [PubMed] [Europe PMC] [Abstract]
- "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
- "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation."J. Biol. Chem. 274:34337-34342(1999) [PubMed] [Europe PMC] [Abstract]
- "Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation."Oncogene 18:4515-4521(1999) [PubMed] [Europe PMC] [Abstract]