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Protein Tyrosine Phosphatase Receptor Type F (PTPRF)

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PTPR-F; LAR; Leukocyte common antigen related

Protein Tyrosine Phosphatase Receptor Type F (PTPRF)
CCC C261
HGNC 9670
MGI 102695
PubMed 7665159
RGD 3453
UniProt P10586
Wiki PTPRF

Receptor-type tyrosine-protein phosphatase F is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC261Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC261Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type F (PTPRF) WB; IHC; ICC; IP.
Assay Kits SEC261Hu ELISA Kit for Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type F (PTPRF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type F (PTPRF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type F (PTPRF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type F (PTPRF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type F (PTPRF) ELISA Kit Customized Service Offer
  1. "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen."J. Exp. Med. 168:1523-1530(1988) [PubMed] [Europe PMC] [Abstract]
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  6. "Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR."EMBO J. 9:2399-2407(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells."J. Biol. Chem. 272:448-457(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration."Mol. Cell. Biol. 33:1430-1441(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the tandem phosphatase domains of RPTP LAR."Cell 97:449-457(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structures of FN3 domains of human receptor-type tyrosine-protein phosphatase F."Submitted (AUG-2007) to the PDB data bank
  16. "Homozygous truncating PTPRF mutation causes athelia."Hum. Genet. 133:1041-1047(2014) [PubMed] [Europe PMC] [Abstract]