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Centromere Protein J (CENPJ)

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LAP; LIP1; BM032; CPAP; MCPH6; Microcephaly,Primary Autosomal Recessive 6; Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1

Centromere Protein J (CENPJ)
CCC C263
HGNC 17272
MGI 2684927
PubMed 20522431
RGD 1310464
UniProt Q9HC77
Wiki CENPJ

Centromere protein J is a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome.

This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC263Hu01 Recombinant Centromere Protein J (CENPJ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC263Hu01 Polyclonal Antibody to Centromere Protein J (CENPJ) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Centromere Protein J (CENPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein J (CENPJ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC263Mu01 Recombinant Centromere Protein J (CENPJ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC263Mu01 Polyclonal Antibody to Centromere Protein J (CENPJ) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Centromere Protein J (CENPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein J (CENPJ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein J (CENPJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein J (CENPJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein J (CENPJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein J (CENPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein J (CENPJ) ELISA Kit Customized Service Offer
  1. "Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex."Mol. Cell. Biol. 20:7813-7825(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly."Mol. Biol. Cell 15:2697-2706(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Plk4-induced centriole biogenesis in human cells."Dev. Cell 13:190-202(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Role of CAP350 in centriolar tubule stability and centriole assembly."PLoS ONE 3:E3855-E3855(2008) [PubMed] [Europe PMC] [Abstract]
  9. "PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle."EMBO J. 29:2395-2406(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Novel CENPJ mutation causes Seckel syndrome."J. Med. Genet. 47:411-414(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Asterless is a scaffold for the onset of centriole assembly."Nature 467:714-718(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size."Nat. Genet. 37:353-355(2005) [PubMed] [Europe PMC] [Abstract]
  14. ErratumNat. Genet. 37:555-555(2005)