≡

Disrupted In Schizophrenia 1 (DISC1)

[Edit]

SCZD9

Disrupted In Schizophrenia 1 (DISC1)
CCC C265
HGNC 2888
MGI 2447658
PubMed 12812986
RGD 631359
UniProt Q9NRI5
Wiki DISC1

  • Disrupted-in-Schizophrenia 1 or DISC1 is a protein with a wide array of functions. It participates in cell growth, movement, axonal growth and transport, neural positioning. Disruptions in DISC1 structure may play an important role at least in some cases of schizophrenia, however the evidence from genetic linkage and association studies suggests that variants of DISC1 do not play a significant role in most cases of schizophrenia, although DISC1 may be more important in bipolar disorder. In humans, this protein is encoded by the DISC1 gene.

  • This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC265Hu01 Recombinant Disrupted In Schizophrenia 1 (DISC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC265Hu01 Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Disrupted In Schizophrenia 1 (DISC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disrupted In Schizophrenia 1 (DISC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC265Mu01 Recombinant Disrupted In Schizophrenia 1 (DISC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC265Mu01 Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Disrupted In Schizophrenia 1 (DISC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disrupted In Schizophrenia 1 (DISC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC265Ra01 Recombinant Disrupted In Schizophrenia 1 (DISC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC265Ra01 Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Disrupted In Schizophrenia 1 (DISC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disrupted In Schizophrenia 1 (DISC1) ELISA Kit Customized Service Offer
  1. "Disruption of two novel genes by a translocation co-segregating with schizophrenia."Hum. Mol. Genet. 9:1415-1423(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Evolutionary constraints on the Disrupted in Schizophrenia locus."Genomics 81:67-77(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms."Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Chromosome 1 loci in Finnish schizophrenia families."Hum. Mol. Genet. 10:1611-1617(2001) [PubMed] [Europe PMC] [Abstract]
  7. "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation."Hum. Mol. Genet. 12:1591-1608(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects."Hum. Mol. Genet. 12:3151-3159(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth."Proc. Natl. Acad. Sci. U.S.A. 100:289-294(2003) [PubMed] [Europe PMC] [Abstract]
  10. ErratumProc. Natl. Acad. Sci. U.S.A. 101:13969-13969(2004)
  11. "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder."Am. J. Hum. Genet. 75:862-872(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders."Mol. Cell. Neurosci. 25:42-55(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site."Mol. Cell. Neurosci. 28:613-624(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia."Proc. Natl. Acad. Sci. U.S.A. 102:8627-8632(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs."Hum. Mol. Genet. 15:1245-1258(2006) [PubMed] [Europe PMC] [Abstract]
  16. "DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1."Hum. Mol. Genet. 15:3313-3323(2006) [PubMed] [Europe PMC] [Abstract]
  17. "DISC1-kendrin interaction is involved in centrosomal microtubule network formation."Biochem. Biophys. Res. Commun. 377:1051-1056(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Disc1 regulates granule cell migration in the developing hippocampus."Hum. Mol. Genet. 18:3286-3297(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling."Cell 136:1017-1031(2009) [PubMed] [Europe PMC] [Abstract]
  20. "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."J. Biol. Chem. 287:7411-7426(2012) [PubMed] [Europe PMC] [Abstract]