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11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)

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11DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; SDR26C1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short Chain Dehydrogenase/Reductase Family 26C,Member 1

11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)
CCC C268
HGNC 5208
MGI 103562
PubMed 21622477
RGD 2834
UniProt P28845
Wiki HSD11B1

11b-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Hu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC268Hu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
MAC268Hu22 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
Assay Kits SEC268Hu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Mu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC268Mu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
Assay Kits SEC268Mu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Ra01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC268Ra01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
MAC268Ra21 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
Assay Kits SEC268Ra ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization."J. Biol. Chem. 266:16653-16658(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism."J. Clin. Endocrinol. Metab. 87:4984-4990(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane."J. Biol. Chem. 274:28762-28770(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency."Nat. Genet. 34:434-439(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase."J. Biol. Chem. 279:31131-31138(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation."J. Biol. Chem. 280:4639-4648(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors." Bioorg. Med. Chem. Lett. 17:527-532(2007) [PubMed] [Europe PMC] [Abstract]
  13. "The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors." Bioorg. Med. Chem. Lett. 17:6056-6061(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1." Bioorg. Med. Chem. Lett. 18:3168-3172(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor."Chem. Biol. Drug Des. 71:36-44(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model." J. Med. Chem. 51:3953-3960(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors."Bioorg. Med. Chem. Lett. 19:1797-1801(2009) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]