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2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP)

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2,3CNP; 2,3-CNP; CNPCNP1; Cyclic-CMP Phosphodiesterase; 2',3'-Cyclic AMP Phosphodiesterase; CNPase; 2':3'-CNMP-3'-ase

2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP)
CCC C269
HGNC 2158
MGI 88437
PubMed 11032883
RGD 2368
UniProt P09543

2,3-CNP is a myelin-associated enzyme that makes up 4% of total CNS myelin protein, and is thought to undergo significant age-associated changes. CNP is expressed exclusively by oligodendrocytes in the CNS, and the appearance of CNP seems to be one of the earliest events of oligodendrocyte differentiation.CNP is thought to play a critical role in the events leading up to myelination.CNP also associates with microtubules in brain tissue and FRTL-5 thyroid cells, and is reported to have Microtubule-associated protein-like activity, being able to catalyze microtubule formation at low molar ratios. Deletion of the C-terminus of CNP or phosphorylation abolish the catalytic activity of microtubule formation. CNP can link tubulin to cellular membranes, and might be involved in the regulation cytoplasmic microtubule distribution.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC269Hu01 Recombinant 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC269Hu01 Polyclonal Antibody to 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) CLIA Kit Customized Service Offer
n/a ELISA Kit for 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC269Mu01 Recombinant 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC269Mu01 Polyclonal Antibody to 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) CLIA Kit Customized Service Offer
n/a ELISA Kit for 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Polyclonal Antibody Customized Service Offer
Assay Kits SEC269Ra ELISA Kit for 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction in central nervous system myelin."Biochem. Soc. Trans. 20:621-626(1992) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and amino acid sequence of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase."Biochem. Biophys. Res. Commun. 152:837-842(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase."Gene 129:297-301(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene."Ann. Hum. Genet. 56:243-254(1992) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The epitope recognized by a monoclonal antibody in the myelin-associated protein CNP."Biochem. Biophys. Res. Commun. 237:266-270(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the catalytic fragment of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase."J. Mol. Biol. 346:789-800(2005) [PubMed] [Europe PMC] [Abstract]