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Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT)

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AASD-PPT; CGI80; LYS2; LYS5; 4'-phosphopantetheinyl transferase; LYS5 ortholog; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase

Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT)
CCC C272
HGNC 14235
MGI 1914868
PubMed 8654981
RGD 1311360
UniProt Q9NRN7
Wiki AASDHPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC272Hu01 Recombinant Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC272Hu01 Polyclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) WB; IHC; ICC; IP.
MAC272Hu21 Monoclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) WB; IHC; ICC; IP.
Assay Kits SEC272Hu ELISA Kit for Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT) ELISA Kit Customized Service Offer
  1. "Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene."Mol. Genet. Metab. 72:336-342(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (MAR-2007) to UniProtKB
  10. "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity."J. Biol. Chem. 278:33142-33149(2003) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Mechanism and substrate recognition of human holo ACP synthase."Chem. Biol. 14:1243-1253(2007) [PubMed] [Europe PMC] [Abstract]