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Adrenocortical Dysplasia Homolog (ACD)

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TPP1; PIP1; PTOP; TINT1; TIN2 Interacting Protein 1; POT1 And TIN2 Organizing Protein

Adrenocortical Dysplasia Homolog (ACD)
CCC C273
HGNC 25070
MGI 87873
PubMed 24513288
RGD 1565053
UniProt Q96AP0
Wiki ACD_(gene

Adrenocortical dysplasia protein homolog is  a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere.

Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC273Hu01 Recombinant Adrenocortical Dysplasia Homolog (ACD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adrenocortical Dysplasia Homolog (ACD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenocortical Dysplasia Homolog (ACD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adrenocortical Dysplasia Homolog (ACD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenocortical Dysplasia Homolog (ACD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC273Mu01 Recombinant Adrenocortical Dysplasia Homolog (ACD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC273Mu01 Polyclonal Antibody to Adrenocortical Dysplasia Homolog (ACD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Adrenocortical Dysplasia Homolog (ACD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenocortical Dysplasia Homolog (ACD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC273Ra01 Recombinant Adrenocortical Dysplasia Homolog (ACD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC273Ra01 Polyclonal Antibody to Adrenocortical Dysplasia Homolog (ACD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Adrenocortical Dysplasia Homolog (ACD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenocortical Dysplasia Homolog (ACD) ELISA Kit Customized Service Offer
  1. "PTOP interacts with POT1 and regulates its localization to telomeres."Nat. Cell Biol. 6:673-680(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator."Hum. Mol. Genet. 14:113-123(2005) [PubMed] [Europe PMC] [Abstract]
  6. "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex."Genes Dev. 18:1649-1654(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."J. Biol. Chem. 279:47264-47271(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."J. Biol. Chem. 279:51338-51342(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Shelterin: the protein complex that shapes and safeguards human telomeres."Genes Dev. 19:2100-2110(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly."Proc. Natl. Acad. Sci. U.S.A. 103:11874-11879(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."J. Biol. Chem. 284:26725-26731(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Functional interaction between telomere protein TPP1 and telomerase."Genes Dev. 24:613-622(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "The POT1-TPP1 telomere complex is a telomerase processivity factor."Nature 445:506-510(2007) [PubMed] [Europe PMC] [Abstract]