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Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1)

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ACOX; PALMCOX; SCOX; Peroxisomal Acyl-Coenzyme A Oxidase 1; Straight-chain acyl-CoA oxidase

Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1)
CCC C275
HGNC 119
MGI 1330812
PubMed 20195242
RGD 619757
UniProt Q15067
Wiki ACOX1

Peroxisomal acyl-coenzyme A oxidase 1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.The deduced human protein sequence is 89% similar to the rat protein. Like the rat homolog, the human sequence also contains C-terminal ser-lys-leu (SKL) residues which function as a peroxisomal targeting signal. Two mRNA species, 1.9-kb and 2.1-kb, were identified in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC275Hu01 Recombinant Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC275Hu01 Polyclonal Antibody to Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) WB; IHC; ICC; IP.
Assay Kits SEC275Hu ELISA Kit for Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) ELISA Kit Customized Service Offer
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  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform."Lab. Invest. 90:696-708(2010) [PubMed] [Europe PMC] [Abstract]
  14. ErratumLab. Invest. 90:808-808(2010)
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Peroxisomal acyl-CoA oxidase deficiency."J. Pediatr. 140:128-130(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency."Hum. Mutat. 28:904-912(2007) [PubMed] [Europe PMC] [Abstract]