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Aminoacylase 1 (ACY1)

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ACY1-D; ACY1D; ACYLASE; N-acyl-L-amino-acid amidohydrolase

Aminoacylase 1 (ACY1)
CCC C276
HGNC 177
MGI 87913
PubMed 17516490
RGD 2030
UniProt Q03154
Wiki ACY1

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids.

ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC276Hu01 Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC276Hu01 Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC
MAC276Hu22 Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
Assay Kits SEC276Hu ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoacylase 1 (ACY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoacylase 1 (ACY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoacylase 1 (ACY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoacylase 1 (ACY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoacylase 1 (ACY1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoacylase 1 (ACY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoacylase 1 (ACY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoacylase 1 (ACY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoacylase 1 (ACY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoacylase 1 (ACY1) ELISA Kit Customized Service Offer
  1. "The nucleotide sequence of human aminoacylase-1."Biochim. Biophys. Acta 1174:201-203(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer."J. Biol. Chem. 268:17010-17017(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family."J. Biol. Chem. 278:44496-44504(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Aminoacylase I deficiency: a novel inborn error of metabolism."Biochem. Biophys. Res. Commun. 338:1322-1326(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism."Am. J. Hum. Genet. 78:401-409(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Neurological findings in aminoacylase 1 deficiency."Neurology 68:2151-2153(2007) [PubMed] [Europe PMC] [Abstract]
  13. "The molecular basis of aminoacylase 1 deficiency."Biochim. Biophys. Acta 1812:685-690(2011) [PubMed] [Europe PMC] [Abstract]