≡

Actin Filament Associated Protein 1 (AFAP1)

[Edit]

AFAP-110; 110 kDa actin filament-associated protein

Actin Filament Associated Protein 1 (AFAP1)
CCC C283
HGNC 24017
MGI 1917542
PubMed 23333711
RGD 619959
UniProt Q8N556
Wiki AFAP1
Actin filament associated protein 1 is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.
Can cross-link actin filaments into both network and bundle structures By similarity. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Filament Associated Protein 1 (AFAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Filament Associated Protein 1 (AFAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Filament Associated Protein 1 (AFAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Filament Associated Protein 1 (AFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Filament Associated Protein 1 (AFAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC283Mu01 Recombinant Actin Filament Associated Protein 1 (AFAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC283Mu01 Polyclonal Antibody to Actin Filament Associated Protein 1 (AFAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Actin Filament Associated Protein 1 (AFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Filament Associated Protein 1 (AFAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Filament Associated Protein 1 (AFAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Filament Associated Protein 1 (AFAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Filament Associated Protein 1 (AFAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Filament Associated Protein 1 (AFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Filament Associated Protein 1 (AFAP1) ELISA Kit Customized Service Offer
  1. "Conversion of mechanical force into biochemical signaling."J. Biol. Chem. 279:54793-54801(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells."J. Cell. Physiol. 213:740-749(2007) [PubMed] [Europe PMC] [Abstract]
  7. "AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts."J. Clin. Invest. 117:2962-2973(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]