≡

Afamin (AFM)

[Edit]

ALB2; ALBA; ALF; A-ALB; Alpha-Albumin

Afamin (AFM)
CCC C284
HGNC 316
MGI 2429409
PubMed 15952736
RGD 628614
UniProt P43652
Wiki Afamin

Afamin is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. The 'new' gene, called alpha-albumin, was located 10 kb downstream from the AFP locus. The gene is selectively expressed in the liver at late stages of development. The mRNA sequence encodes a predicted secreted protein with the typical triple domain disulfide cross-linked structure. Comparisons of coding and promoter sequences suggested that ALBA could be a phylogenetic intermediate between the ALB and AFP genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC284Hu01 Recombinant Afamin (AFM) Positive Control; Immunogen; SDS-PAGE; WB.
RPC284Hu02 Recombinant Afamin (AFM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC284Hu01 Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
MAC284Hu22 Monoclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
PAC284Hu02 Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
LAC284Hu71 Biotin-Linked Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC.
Assay Kits SEC284Hu ELISA Kit for Afamin (AFM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC284Mu01 Recombinant Afamin (AFM) Positive Control; Immunogen; SDS-PAGE; WB.
APC284Mu01 Active Afamin (AFM) Cell culture; Activity Assays.
Antibodies PAC284Mu01 Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
LAC284Mu71 Biotin-Linked Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC.
LAC284Mu81 FITC-Linked Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Afamin (AFM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Afamin (AFM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC284Ra01 Recombinant Afamin (AFM) Positive Control; Immunogen; SDS-PAGE; WB.
CPC284Ra21 OVA Conjugated Afamin (AFM) Immunogen; SDS-PAGE; WB.
Antibodies PAC284Ra01 Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
MAC284Ra21 Monoclonal Antibody to Afamin (AFM) WB
PAC284Ra08 Polyclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
MAC284Ra22 Monoclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
MAC284Ra23 Monoclonal Antibody to Afamin (AFM) WB
MAC284Ra24 Monoclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
MAC284Ra25 Monoclonal Antibody to Afamin (AFM) WB; IHC; ICC; IP.
Assay Kits CEC284Ra ELISA Kit for Afamin (AFM) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family."J. Biol. Chem. 269:18149-18154(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family."Proc. Natl. Acad. Sci. U.S.A. 93:7557-7561(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of rat alpha-albumin and cDNA cloning of its human ortholog."Gene 153:287-288(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression."J. Proteome Res. 4:889-899(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the vitamin E-binding properties of human plasma afamin."Biochemistry 41:14532-14538(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier."J. Neurochem. 108:707-718(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]