≡

Angiotensin II Receptor Associated Protein (AGTRAP)

[Edit]

ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein

Angiotensin II Receptor Associated Protein (AGTRAP)
CCC C286
HGNC 13539
MGI 1339977
PubMed 11733189
RGD 1359346
UniProt Q6RW13
Wiki AGTRAP

Type-1 angiotensin II receptor-associated protein is a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

AGTRAP appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC286Mu01 Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiotensin II Receptor Associated Protein (AGTRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiotensin II Receptor Associated Protein (AGTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits SEC286Ra ELISA Kit for Angiotensin II Receptor Associated Protein (AGTRAP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."Int. J. Biochem. Cell Biol. 34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."Mol. Biol. Cell 14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]