≡

A Kinase Anchor Protein 1 (AKAP1)

[Edit]

AKAP121; AKAP149; AKAP84; D-AKAP1; A-kinase anchor protein 149 kDa; A Kinase, PRKA Anchor Protein 1,Mitochondrial; Dual specificity A-kinase-anchoring protein 1

A Kinase Anchor Protein 1 (AKAP1)
CCC C291
HGNC 367
MGI 104729
PubMed 24412345
RGD 620826
UniProt Q92667
Wiki AKAP1
The A kinase anchor protein 1, mitochondrial binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
PP1 and RNA binding to this same site was mutually exclusive and controlled through a novel, phosphorylation-dependent mechanism. A collapse of the mitochondrial network was observed upon introduction of RNA-binding deficient mutants of AKAP149, pointing to the importance of RNA tethering to the mitochondrial membrane by AKAP149 for mitochondrial distribution.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC291Hu01 Recombinant A Kinase Anchor Protein 1 (AKAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 1 (AKAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 1 (AKAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 1 (AKAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 1 (AKAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 1 (AKAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 1 (AKAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 1 (AKAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 1 (AKAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 1 (AKAP1) ELISA Kit Customized Service Offer
  1. "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain."Biochem. Biophys. Res. Commun. 225:313-319(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells."J. Biol. Chem. 270:27804-27811(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]