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Autocrine Motility Factor Receptor (AMFR)

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GP78; RNF45; E3 ubiquitin-protein ligase AMFR; RING finger protein 45

Autocrine Motility Factor Receptor (AMFR)
CCC C294
HGNC 463
MGI 1345634
PubMed 1655517
RGD 1311551
UniProt Q9UKV5
Wiki AMFR

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. Autocrine motility factor receptor is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.

Specific receptor for the autocrine motility factor. Possesses ubiquitin ligase activity and can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome- mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC294Hu01 Recombinant Autocrine Motility Factor Receptor (AMFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC294Hu01 Polyclonal Antibody to Autocrine Motility Factor Receptor (AMFR) WB; IHC; ICC; IP.
Assay Kits SEC294Hu ELISA Kit for Autocrine Motility Factor Receptor (AMFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC294Mu01 Recombinant Autocrine Motility Factor Receptor (AMFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC294Mu01 Polyclonal Antibody to Autocrine Motility Factor Receptor (AMFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Autocrine Motility Factor Receptor (AMFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autocrine Motility Factor Receptor (AMFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autocrine Motility Factor Receptor (AMFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autocrine Motility Factor Receptor (AMFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autocrine Motility Factor Receptor (AMFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autocrine Motility Factor Receptor (AMFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autocrine Motility Factor Receptor (AMFR) ELISA Kit Customized Service Offer
  1. "The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein."FEBS Lett. 456:295-300(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor."Biochem. Biophys. Res. Commun. 212:727-742(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor."J. Biol. Chem. 266:13442-13448(1991) [PubMed] [Europe PMC] [Abstract]
  5. "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum."Proc. Natl. Acad. Sci. U.S.A. 98:14422-14427(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Overexpression of the tumor autocrine motility factor receptor, gp78, a ubiquitin protein ligase (E3), results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in Hep G2 cells."J. Biol. Chem. 278:23984-23988(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."Mol. Cell 19:829-840(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane."Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."Arch. Biochem. Biophys. 483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of RSGI RUH-076, a human CUE domain."Submitted (SEP-2007) to the PDB data bank
  13. "The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97."J. Biol. Chem. 286:38679-38690(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]