≡

Anthrax Toxin Receptor 1 (ANTXR1)

[Edit]

ATR; TEM8; Tumor Endothelial Marker 8

Anthrax Toxin Receptor 1 (ANTXR1)
CCC C297
HGNC 21014
MGI 1916788
PubMed 20034073
RGD 1307144
UniProt Q9H6X2
Wiki ANTXR1

Anthrax toxin receptor 1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer.

This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC297Hu01 Recombinant Anthrax Toxin Receptor 1 (ANTXR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC297Hu ELISA Kit for Anthrax Toxin Receptor 1 (ANTXR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anthrax Toxin Receptor 1 (ANTXR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anthrax Toxin Receptor 1 (ANTXR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anthrax Toxin Receptor 1 (ANTXR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anthrax Toxin Receptor 1 (ANTXR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anthrax Toxin Receptor 1 (ANTXR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anthrax Toxin Receptor 1 (ANTXR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anthrax Toxin Receptor 1 (ANTXR1) ELISA Kit Customized Service Offer
  1. "Genes expressed in human tumor endothelium."Science 289:1197-1202(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the cellular receptor for anthrax toxin."Nature 414:225-229(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants."PLoS ONE 7:E43174-E43174(2012) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor."Proc. Natl. Acad. Sci. U.S.A. 100:5170-5174(2003) [PubMed] [Europe PMC] [Abstract]
  8. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  9. "TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen."Exp. Cell Res. 305:133-144(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton."J. Biol. Chem. 281:23227-23236(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in ANTXR1 cause GAPO syndrome." Am. J. Hum. Genet. 92:792-799(2013) [PubMed] [Europe PMC] [Abstract]
  14. "The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin."PLoS ONE 5:E11203-E11203(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma."Nat. Med. 14:1236-1246(2008) [PubMed] [Europe PMC] [Abstract]