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Adenomatosis Polyposis Coli Protein (APC)

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DP2; DP2.5; DP3; FAP; FPC; GS; Deleted in polyposis 2.5

Adenomatosis Polyposis Coli Protein (APC)
CCC C314
HGNC 583
MGI 88039
PubMed 11283619
RGD 2123
UniProt P25054
Wiki APC

APC (adenomatosis polyposis coli) is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, or whether a cell moves within or away from a tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC314Hu01 Recombinant Adenomatosis Polyposis Coli Protein (APC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC314Hu01 Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) WB; IHC; ICC; IP.
MAC314Hu22 Monoclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) WB; IHC; ICC; IP.
Assay Kits SEC314Hu ELISA Kit for Adenomatosis Polyposis Coli Protein (APC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC314Mu01 Recombinant Adenomatosis Polyposis Coli Protein (APC) Positive Control; Immunogen; SDS-PAGE; WB.
RPC314Mu02 Recombinant Adenomatosis Polyposis Coli Protein (APC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC314Mu01 Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) WB; IHC; ICC; IP.
PAC314Mu02 Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) WB; IHC; ICC; IP.
Assay Kits SEC314Mu ELISA Kit for Adenomatosis Polyposis Coli Protein (APC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC314Ra01 Recombinant Adenomatosis Polyposis Coli Protein (APC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC314Ra01 Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Adenomatosis Polyposis Coli Protein (APC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenomatosis Polyposis Coli Protein (APC) ELISA Kit Customized Service Offer
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  29. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
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  32. "Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex."EMBO J. 20:6203-6212(2001) [PubMed] [Europe PMC] [Abstract]
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  35. "Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain."Biochemistry 49:5143-5153(2010) [PubMed] [Europe PMC] [Abstract]
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  39. "Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma."Hum. Mol. Genet. 1:559-563(1992) [PubMed] [Europe PMC] [Abstract]
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  41. "Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene."Eur. J. Cancer 30A:1709-1713(1994) [PubMed] [Europe PMC] [Abstract]
  42. "Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients."Hum. Mol. Genet. 3:1687-1688(1994) [PubMed] [Europe PMC] [Abstract]
  43. ErratumHum. Mol. Genet. 3:1918-1918(1994)
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  46. "Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis."Hum. Mutat. 9:7-16(1997) [PubMed] [Europe PMC] [Abstract]
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  48. "The APC I1307K allele and breast cancer risk." Nat. Genet. 20:13-14(1998) [PubMed] [Europe PMC] [Abstract]
  49. "The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history."Proc. Natl. Acad. Sci. U.S.A. 95:10722-10727(1998) [PubMed] [Europe PMC] [Abstract]
  50. "The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews."Nat. Genet. 20:62-65(1998) [PubMed] [Europe PMC] [Abstract]
  51. "Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism."Am. J. Hum. Genet. 64:378-384(1999) [PubMed] [Europe PMC] [Abstract]
  52. "Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition."J. Med. Genet. 36:14-20(1999) [PubMed] [Europe PMC] [Abstract]
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  55. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]