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B-Cell CLL/Lymphoma 10 (Bcl10)

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CARMEN; CIPER; CLAP; c-E10; mE10; CARD-containing molecule enhancing NF-kappa-B; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN

B-Cell CLL/Lymphoma 10 (Bcl10)
CCC C326
HGNC 989
MGI 1337994
PubMed 10319863
RGD 620544
UniProt O95999
Wiki BCL10

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. B-cell lymphoma/leukemia 10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC326Hu01 Recombinant B-Cell CLL/Lymphoma 10 (Bcl10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC326Hu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 10 (Bcl10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC326Mu01 Recombinant B-Cell CLL/Lymphoma 10 (Bcl10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC326Mu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 10 (Bcl10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 10 (Bcl10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 10 (Bcl10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 10 (Bcl10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 10 (Bcl10) ELISA Kit Customized Service Offer
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  2. "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10."J. Biol. Chem. 274:9955-9961(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]
  4. "mE10, a novel caspase recruitment domain-containing proapoptotic molecule."J. Biol. Chem. 274:10287-10292(1999) [PubMed] [Europe PMC] [Abstract]
  5. "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis."J. Biol. Chem. 274:17946-17954(1999) [PubMed] [Europe PMC] [Abstract]
  6. "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB."J. Biol. Chem. 274:20127-20132(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)."Nat. Genet. 22:63-68(1999) [PubMed] [Europe PMC] [Abstract]
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  9. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling."Oncogene 20:4317-4323(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."J. Biol. Chem. 282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10."Proc. Natl. Acad. Sci. U.S.A. 104:908-913(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The proteolytic activity of the paracaspase MALT1 is key in T cell activation."Nat. Immunol. 9:272-281(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity." J. Clin. Invest. 124:5239-5248(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Absence of BCL10 mutations in human malignant mesothelioma."Cell 97:684-686(1999) [PubMed] [Europe PMC] [Abstract]