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Breakpoint Cluster Region (BCR)

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ALL; BCR/FGFR1; BCR1; CML; FGFR1/BCR; PHL; Renal carcinoma antigen NY-REN-26

Breakpoint Cluster Region (BCR)
CCC C328
HGNC 1014
MGI 88141
PubMed 2487142
RGD 1307993
UniProt P11274
Wiki BCR_gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC328Hu01 Recombinant Breakpoint Cluster Region (BCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC328Hu01 Polyclonal Antibody to Breakpoint Cluster Region (BCR) WB; IHC; ICC; IP.
Assay Kits SEC328Hu ELISA Kit for Breakpoint Cluster Region (BCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC328Mu01 Recombinant Breakpoint Cluster Region (BCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC328Mu01 Polyclonal Antibody to Breakpoint Cluster Region (BCR) WB; IHC; ICC; IP.
Assay Kits SEC328Mu ELISA Kit for Breakpoint Cluster Region (BCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Breakpoint Cluster Region (BCR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Breakpoint Cluster Region (BCR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Breakpoint Cluster Region (BCR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Breakpoint Cluster Region (BCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Breakpoint Cluster Region (BCR) ELISA Kit Customized Service Offer
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  5. ErratumProc. Natl. Acad. Sci. U.S.A. 84:2507-2507(1987)
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  10. "Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript."Blood 75:1146-1153(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines."Mol. Cell. Biol. 11:1854-1860(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Bcr encodes a GTPase-activating protein for p21rac."Nature 351:400-402(1991) [PubMed] [Europe PMC] [Abstract]
  13. "BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner."Cell 66:161-171(1991) [PubMed] [Europe PMC] [Abstract]
  14. "The BCR gene encodes a novel serine/threonine kinase activity within a single exon."Cell 67:459-468(1991) [PubMed] [Europe PMC] [Abstract]
  15. "The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr."J. Biol. Chem. 272:33260-33270(1997) [PubMed] [Europe PMC] [Abstract]
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  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  29. "src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP."J. Biol. Chem. 289:35397-35408(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]