≡

Basic Transcription Factor 3 (BTF3)

[Edit]

BETA-NAC; BTF3a; BTF3b; NACB; Nascent-Polypeptide-Associated Complex Beta Polypeptide; RNA polymerase B transcription factor 3

Basic Transcription Factor 3 (BTF3)
CCC C334
HGNC 1125
MGI 1202875
PubMed 17312387
RGD 1308095
UniProt P20290
Wiki BTF3

Transcription factor BTF3 forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.

Basic transcription factor 3 (BTF3) acts as a transcription factor and modulator of apoptosis, and is differentially expressed in colorectal cancer and glioblastomas. In the present study, the expression of BTF3, as well as its role in apoptosis and gene transcription, was analyzed in pancreatic ductal adenocarcinoma (PDAC). BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Transcription Factor 3 (BTF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Transcription Factor 3 (BTF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Transcription Factor 3 (BTF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Transcription Factor 3 (BTF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Transcription Factor 3 (BTF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Transcription Factor 3 (BTF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Transcription Factor 3 (BTF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Transcription Factor 3 (BTF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Transcription Factor 3 (BTF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Transcription Factor 3 (BTF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Transcription Factor 3 (BTF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Transcription Factor 3 (BTF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Transcription Factor 3 (BTF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Transcription Factor 3 (BTF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Transcription Factor 3 (BTF3) ELISA Kit Customized Service Offer
  1. "Sequencing and expression of complementary DNA for the general transcription factor BTF3."Nature 344:556-559(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the putative BTF3 transcription factor."Gene 117:219-228(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions."J. Biol. Chem. 275:37838-37845(2000) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit."Protein Cell 1:406-416(2010) [PubMed] [Europe PMC] [Abstract]