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Bradykinin Receptor B2 (BDKRB2)

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BDKR-B2; B2R; BK2; BKR2; BRB2

Bradykinin Receptor B2 (BDKRB2)
CCC C344
HGNC 1030
MGI 102845
PubMed 16461337
RGD 2201
UniProt P30411
Wiki BDKKB2

Bradykinin receptor B2 (B2) is a g-protein coupled receptor for bradykinin, encoded by the BDKRB2. The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.Kallidin also signals through the B2 receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC344Hu01 Recombinant Bradykinin Receptor B2 (BDKRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Bradykinin Receptor B2 (BDKRB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bradykinin Receptor B2 (BDKRB2) Polyclonal Antibody Customized Service Offer
Assay Kits SEC344Hu ELISA Kit for Bradykinin Receptor B2 (BDKRB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bradykinin Receptor B2 (BDKRB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bradykinin Receptor B2 (BDKRB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bradykinin Receptor B2 (BDKRB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bradykinin Receptor B2 (BDKRB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bradykinin Receptor B2 (BDKRB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC344Ra01 Recombinant Bradykinin Receptor B2 (BDKRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC344Ra01 Polyclonal Antibody to Bradykinin Receptor B2 (BDKRB2) WB; IHC; ICC; IP.
MAC344Ra21 Monoclonal Antibody to Bradykinin Receptor B2 (BDKRB2) WB; IHC; ICC; IP.
Assay Kits SEC344Ra ELISA Kit for Bradykinin Receptor B2 (BDKRB2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor."Biochem. Biophys. Res. Commun. 184:260-268(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14."Genomics 15:435-438(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity."Mol. Pharmacol. 44:346-355(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene."Biochem. Biophys. Res. Commun. 187:1306-1313(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor."Genomics 23:362-369(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of polymorphic sites of the human bradykinin B2 receptor gene."Biochem. Biophys. Res. Commun. 211:234-240(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of the bradykinin B2 receptors' amino terminus."Biochemistry 35:7514-7519(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function."J. Biol. Chem. 276:40431-40440(2001) [PubMed] [Europe PMC] [Abstract]