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Butyrylcholinesterase (BCHE)

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BuChE; CHE1; E1; Pseudocholinesterase; Cholinesterase; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II

Butyrylcholinesterase (BCHE)
CCC C348
HGNC 983
MGI 894278
PubMed 11848688
RGD 619996
UniProt P06276
Wiki BCHE

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. Butyrylcholinesterase is believed to play a role in the body's ability to metabolize the drug cocaine. In 2008, an experimental new drug was discovered for the potential treatment of cocaine abuse and overdose based on the BChE structure. It was shown to remove cocaine from the body 2000 times as fast as the natural form of BChE. Studies in rats have shown that the drug prevented convulsions and death when administered cocaine overdoses.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC348Hu01 Recombinant Butyrylcholinesterase (BCHE) Positive Control; Immunogen; SDS-PAGE; WB.
RPC348Hu02 Recombinant Butyrylcholinesterase (BCHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC348Hu01 Polyclonal Antibody to Butyrylcholinesterase (BCHE) WB; IHC; ICC; IP.
MAC348Hu22 Monoclonal Antibody to Butyrylcholinesterase (BCHE) WB; IHC; ICC; IP.
PAC348Hu02 Polyclonal Antibody to Butyrylcholinesterase (BCHE) WB; IHC; ICC; IP.
Assay Kits SEC348Hu ELISA Kit for Butyrylcholinesterase (BCHE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Butyrylcholinesterase (BCHE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Butyrylcholinesterase (BCHE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Butyrylcholinesterase (BCHE) Polyclonal Antibody Customized Service Offer
Assay Kits CEC348Mu ELISA Kit for Butyrylcholinesterase (BCHE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC348Ra01 Recombinant Butyrylcholinesterase (BCHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC348Ra01 Polyclonal Antibody to Butyrylcholinesterase (BCHE) WB; IHC; ICC; IP.
MAC348Ra21 Monoclonal Antibody to Butyrylcholinesterase (BCHE) WB; IHC; ICC; IP.
Assay Kits SEC348Ra ELISA Kit for Butyrylcholinesterase (BCHE) Enzyme-linked immunosorbent assay for Antigen Detection.
CEC348Ra ELISA Kit for Butyrylcholinesterase (BCHE) Enzyme-linked immunosorbent assay for Antigen Detection.
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  42. "Novel mutations in the BCHE gene in patients with no butyrylcholinesterase activity."Clin. Chim. Acta 351:155-159(2005) [PubMed] [Europe PMC] [Abstract]
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  46. "Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia."Pharmacogenet. Genomics 17:995-999(2007) [PubMed] [Europe PMC] [Abstract]
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  48. "Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), 'silent' with mivacurium."Biochem. Pharmacol. 92:476-483(2014) [PubMed] [Europe PMC] [Abstract]