≡

Calcineurin Binding Protein 1 (CABIN1)

[Edit]

CAIN; PPP3IN; Calcineurin inhibitor

Calcineurin Binding Protein 1 (CABIN1)
CCC C351
HGNC 24187
MGI 1298375
PubMed 10933397
RGD 620263
UniProt Q9Y6J0
Wiki CABIN1

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. Calcineurin-binding protein cabin-1 binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction.

The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC351Hu01 Recombinant Calcineurin Binding Protein 1 (CABIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC351Hu01 Polyclonal Antibody to Calcineurin Binding Protein 1 (CABIN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcineurin Binding Protein 1 (CABIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcineurin Binding Protein 1 (CABIN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC351Mu01 Recombinant Calcineurin Binding Protein 1 (CABIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC351Mu01 Polyclonal Antibody to Calcineurin Binding Protein 1 (CABIN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcineurin Binding Protein 1 (CABIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcineurin Binding Protein 1 (CABIN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcineurin Binding Protein 1 (CABIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcineurin Binding Protein 1 (CABIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcineurin Binding Protein 1 (CABIN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcineurin Binding Protein 1 (CABIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcineurin Binding Protein 1 (CABIN1) ELISA Kit Customized Service Offer
  1. "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes."Immunity 8:703-711(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."Cell 116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress."Nucleic Acids Res. 41:2180-2190(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."Nature 422:730-734(2003) [PubMed] [Europe PMC] [Abstract]