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Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1)

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CACN-B1; CAB1; CACNLB1; CCHLB1; Voltage-dependent L-type calcium channel subunit beta-1

Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1)
CCC C352
HGNC 1401
MGI 102522
PubMed 16368137
RGD 68382
UniProt Q02641
Wiki CACNB1
Voltage-dependent L-type calcium channel subunit beta-1 is a protein belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, Beta 1 Subunit (CACNb1) ELISA Kit Customized Service Offer
  1. "Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene."J. Biol. Chem. 267:22967-22972(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype."Neuron 8:71-84(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart."Circ. Res. 72:1337-1344(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes."Neurosci. Lett. 217:13-16(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels."Neurosci. Lett. 277:111-114(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility."Hum. Mol. Genet. 2:863-868(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly."Neuropharmacology 32:1089-1102(1993) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]