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Calcium Dependent Secretion Activator (CADPS)

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CAPS; CAPS1; Calcium-dependent activator protein for secretion 1

Calcium Dependent Secretion Activator (CADPS)
CCC C354
HGNC 1426
MGI 1350922
PubMed 23801330
RGD 708573
UniProt Q9ULU8
Wiki CADPS

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2 -regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.

Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC354Hu01 Recombinant Calcium Dependent Secretion Activator (CADPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC354Hu01 Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Dependent Secretion Activator (CADPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Dependent Secretion Activator (CADPS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Dependent Secretion Activator (CADPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Dependent Secretion Activator (CADPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Dependent Secretion Activator (CADPS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Dependent Secretion Activator (CADPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Dependent Secretion Activator (CADPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Dependent Secretion Activator (CADPS) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."Genomics 81:279-291(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis."J. Biol. Chem. 272:19637-19640(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)."Submitted (NOV-2004) to the PDB data bank