≡

Cancer Susceptibility Candidate 3 (CASC3)

[Edit]

BTZ; MLN51; Cancer susceptibility candidate gene 3 protein; Metastatic lymph node gene 51 protein; Protein barentsz

Cancer Susceptibility Candidate 3 (CASC3)
CCC C360
HGNC 17040
MGI 2179723
PubMed 15166247
RGD 628766
UniProt O15234
Wiki CASC3

Protein CASC3 is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.Forms homooligomers (By similarity). Interacts with STAU in an RNA-dependent manner (By similarity). Part of the EJC core complex that contains CASC3, EIF4A3, MAGOH and RBM8A. Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Interacts with EIF4A3, MAGOH, NXF1 and RBM8A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cancer Susceptibility Candidate 3 (CASC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cancer Susceptibility Candidate 3 (CASC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cancer Susceptibility Candidate 3 (CASC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cancer Susceptibility Candidate 3 (CASC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cancer Susceptibility Candidate 3 (CASC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cancer Susceptibility Candidate 3 (CASC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cancer Susceptibility Candidate 3 (CASC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cancer Susceptibility Candidate 3 (CASC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cancer Susceptibility Candidate 3 (CASC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cancer Susceptibility Candidate 3 (CASC3) ELISA Kit Customized Service Offer
  1. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Metastatic lymph node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer."Oncogene 21:4422-4434(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Targets of gene amplification and overexpression at 17q in gastric cancer."Cancer Res. 62:2625-2629(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module."J. Biol. Chem. 279:33702-33715(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity."Nat. Struct. Mol. Biol. 12:861-869(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core."RNA 11:1869-1883(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly."J. Cell Sci. 120:2774-2784(2007) [PubMed] [Europe PMC] [Abstract]
  12. "MLN51 stimulates the RNA-helicase activity of eIF4AIII."PLoS ONE 2:E303-E303(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA."Cell 126:713-725(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA."Science 313:1968-1972(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Mechanism of ATP turnover inhibition in the EJC."RNA 15:67-75(2009) [PubMed] [Europe PMC] [Abstract]