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Cytidine Deaminase (CDA)

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CDD; Cytidine aminohydrolase

Cytidine Deaminase (CDA)
CCC C366
HGNC 1712
MGI 1919519
PubMed 16720547
RGD 1311101
UniProt P32320
Wiki CDA

Cytidine deaminase  forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

Kuhn et al. (1993) identified a cDNA clone corresponding to the human CDA gene in a study of expression products related to monocyte and macrophage differentiation. The deduced 145-residue protein has a molecular mass of 16.1 kD and shows nearly 50% homology to cytidine deaminase from Bacillus subtilis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC366Hu01 Recombinant Cytidine Deaminase (CDA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC366Hu01 Polyclonal Antibody to Cytidine Deaminase (CDA) WB; IHC; ICC/IF
MAC366Hu21 Monoclonal Antibody to Cytidine Deaminase (CDA) WB; IHC; ICC; IP.
Assay Kits SEC366Hu ELISA Kit for Cytidine Deaminase (CDA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytidine Deaminase (CDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytidine Deaminase (CDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytidine Deaminase (CDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytidine Deaminase (CDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytidine Deaminase (CDA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytidine Deaminase (CDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytidine Deaminase (CDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytidine Deaminase (CDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytidine Deaminase (CDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytidine Deaminase (CDA) ELISA Kit Customized Service Offer
  1. "Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA."Cancer Res. 54:5401-5407(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the gene coding for human cytidine deaminase."Biochim. Biophys. Acta 1443:323-333(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Growth inhibition of granulocyte-macrophage colony forming cells by human cytidine deaminase requires the catalytic function of the protein."Blood 91:4127-4135(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation."Biochem. Biophys. Res. Commun. 190:1-7(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human cytidine deaminase bound to a potent inhibitor."J. Med. Chem. 48:658-660(2005) [PubMed] [Europe PMC] [Abstract]