≡

Cell Division Cycle Protein 6 (CDC6)

[Edit]

CDC18L; HsCDC18; HsCDC6; CDC6-related protein; Cdc18-related protein

Cell Division Cycle Protein 6 (CDC6)
CCC C367
HGNC 1744
MGI 1345150
PubMed 9774682
RGD 1309157
UniProt Q99741
Wiki CDC6

Cell division control protein 6 homolog is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 6 (CDC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 6 (CDC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 6 (CDC6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 6 (CDC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 6 (CDC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 6 (CDC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 6 (CDC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 6 (CDC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 6 (CDC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 6 (CDC6) ELISA Kit Customized Service Offer
  1. "A human protein related to yeast Cdc6p."Proc. Natl. Acad. Sci. U.S.A. 94:142-147(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase."Mol. Cell. Biol. 18:2758-2767(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage."Mol. Biol. Cell 18:3340-3350(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses."FEBS Lett. 587:2137-2142(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the pre-replication complex cause Meier-Gorlin syndrome." Nat. Genet. 43:356-359(2011) [PubMed] [Europe PMC] [Abstract]