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Centromere Protein A (CENPA)

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CENP-A; Histone H3-like centromeric protein A; Centromere autoantigen A

Centromere Protein A (CENPA)
CCC C372
HGNC 1851
MGI 88375
PubMed 16622419
RGD 1563607
UniProt P49450
Wiki CENPA

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.

Alternative splicing results in multiple transcript variants encoding distinct isoforms.During the initial formation of a centromere, localization of the CENP-A to the centromere is believed to be controlled by "centromeric" heterochromatin surrounding the centromere, and by a RNAi mechanism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein A (CENPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein A (CENPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein A (CENPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein A (CENPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein A (CENPA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein A (CENPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein A (CENPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein A (CENPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein A (CENPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein A (CENPA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein A (CENPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein A (CENPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein A (CENPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein A (CENPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein A (CENPA) ELISA Kit Customized Service Offer
  1. "Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere."J. Cell Biol. 127:581-592(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites."J. Cell Biol. 136:501-513(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3."Clin. Exp. Immunol. 120:218-223(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0."J. Biol. Chem. 276:5829-5835(2001) [PubMed] [Europe PMC] [Abstract]
  7. "CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis."J. Cell Biol. 155:1147-1157(2001) [PubMed] [Europe PMC] [Abstract]
  8. "CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function."Dev. Cell 5:853-864(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres."Chromosome Res. 12:805-815(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin."Nat. Struct. Mol. Biol. 11:1076-1083(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Structural determinants for generating centromeric chromatin."Nature 430:578-582(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres."Genome Biol. 8:R148.1-R148.19(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis."Cell Cycle 7:787-795(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells."ChemBioChem 9:77-92(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B."J. Biophotonics 1:245-254(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin."J. Cell Biol. 183:1193-1202(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP."Cell 137:472-484(2009) [PubMed] [Europe PMC] [Abstract]
  21. "HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres."Cell 137:485-497(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function."Mol. Cells 27:697-701(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N."Nat. Cell Biol. 11:896-902(2009) [PubMed] [Europe PMC] [Abstract]
  24. "The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation."PLoS ONE 4:E5832-E5832(2009) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres."Nature 467:347-351(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP."Genes Dev. 25:901-906(2011) [PubMed] [Europe PMC] [Abstract]