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Carbohydrate Synthase 1 (CHSY1)

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CSS1; Chondroitin sulfate synthase 1; Chondroitin glucuronyltransferase 1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1

Carbohydrate Synthase 1 (CHSY1)
CCC C380
HGNC 17198
MGI 2681120
PubMed 22280990
RGD 1311904
UniProt Q86X52
Wiki CHSY1

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. lycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.

Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid from UDP-GlcUA and N-acetylgalactosamine from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Synthase 1 (CHSY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC380Hu ELISA Kit for Carbohydrate Synthase 1 (CHSY1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC380Mu01 Recombinant Carbohydrate Synthase 1 (CHSY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Synthase 1 (CHSY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Synthase 1 (CHSY1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Synthase 1 (CHSY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Synthase 1 (CHSY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Synthase 1 (CHSY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Synthase 1 (CHSY1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of a human chondroitin synthase."J. Biol. Chem. 276:38721-38726(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization."J. Biol. Chem. 278:23666-23671(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Chondroitin sulfate synthase-3. Molecular cloning and characterization."J. Biol. Chem. 278:39711-39725(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling."Am. J. Hum. Genet. 87:768-778(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling." Am. J. Hum. Genet. 87:757-767(2010) [PubMed] [Europe PMC] [Abstract]