Cardiotrophin Like Cytokine Factor 1 (CLCF1)
[Edit]CLC; NR6; BSF3; CISS2; NNT1; Novel Neurotrophin-1; B Cell-Stimulating Factor-3
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IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.
CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.The term "neurotrophin" is commonly used to refer collectively to the four structurally related factors NGF, BDNF, NT-3 and NT-4, while NNT1 bears no structural resemblance to these four proteins.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC389Hu01 | Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC389Hu01 | Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. |
| MAC389Hu22 | Monoclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. | |
| LAC389Hu71 | Biotin-Linked Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC. | |
| Assay Kits | SEC389Hu | ELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC389Hu | CLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC389Mu01 | Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC389Mu02 | Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC389Mu01 | Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. |
| PAC389Mu02 | Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC389Mu | ELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC389Mu | CLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC389Ra01 | Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC389Ra01 | Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. |
| MAC389Ra21 | Monoclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC389Ra | ELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC389Ra | CLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1) | Chemiluminescent immunoassay for Antigen Detection. |
- "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family."Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463(1999) [PubMed] [Europe PMC] [Abstract]
- "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family."Biochem. Biophys. Res. Commun. 262:132-138(1999) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient."Proc. Natl. Acad. Sci. U.S.A. 103:10068-10073(2006) [PubMed] [Europe PMC] [Abstract]