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Clathrin Interactor 1 (CLINT1)

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CLINT; ENTH; EPN4; EPNR; EPSINR; EPSIN4; Enthoprotin; Epsin-4; Epsin-related protein; Clathrin-interacting protein localized in the trans-Golgi region

Clathrin Interactor 1 (CLINT1)
CCC C391
HGNC 23186
MGI 2144243
PubMed 19570844
UniProt Q14677
Wiki CLINT1

Clathrin interactor 1 is a protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. This enables a turnover of neuroreceptors or other proteins to be maintained and thus the numbers of receptors can be fine tuned. The CLINT1 gene has been shown to be involved in the genetic aetiology of schizophrenia in four studies  It is known that the antipsychotic drugs chlorpromazine and clozapine stabilise clathrin coated vesicles and this may be one reason why antipsychotic drugs are effective in treating delusions, auditory hallucinations and many of the other symptoms of schizophrenia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clathrin Interactor 1 (CLINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clathrin Interactor 1 (CLINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clathrin Interactor 1 (CLINT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clathrin Interactor 1 (CLINT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clathrin Interactor 1 (CLINT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clathrin Interactor 1 (CLINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clathrin Interactor 1 (CLINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clathrin Interactor 1 (CLINT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clathrin Interactor 1 (CLINT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clathrin Interactor 1 (CLINT1) ELISA Kit Customized Service Offer
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
  7. "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking."J. Cell Biol. 160:213-222(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia."Am. J. Hum. Genet. 76:902-907(2005) [PubMed] [Europe PMC] [Abstract]
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  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]