Coatomer Protein Complex Subunit Alpha (COPa)
[Edit]COP-A; HEP-COP; Alpha-coat protein; Xenin; Xenopsin-related peptide; Proxenin
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The Coatomer subunit alpha shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Coatomer Protein Complex Subunit Alpha (COPa) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Coatomer Protein Complex Subunit Alpha (COPa) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Coatomer Protein Complex Subunit Alpha (COPa) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Coatomer Protein Complex Subunit Alpha (COPa) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Coatomer Protein Complex Subunit Alpha (COPa) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Coatomer Protein Complex Subunit Alpha (COPa) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Coatomer Protein Complex Subunit Alpha (COPa) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Coatomer Protein Complex Subunit Alpha (COPa) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Coatomer Protein Complex Subunit Alpha (COPa) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Coatomer Protein Complex Subunit Alpha (COPa) | ELISA Kit Customized Service Offer |
- "HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex."Gene 169:223-227(1996) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion."J. Biol. Chem. 267:22305-22309(1992) [PubMed] [Europe PMC] [Abstract]
- "Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin."Ann. Hum. Genet. 61:369-373(1997) [PubMed] [Europe PMC] [Abstract]
- "Xenin -- a review."Peptides 19:609-615(1998) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Genome-wide evaluation and discovery of vertebrate A-to-I RNA editing sites."Biochem. Biophys. Res. Commun. 412:407-412(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia." Nat. Genet. 46:1021-1027(2014) [PubMed] [Europe PMC] [Abstract]