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Complexin 1 (CPLX1)

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CPX-I; CPX1; Synaphin-2

Complexin 1 (CPLX1)
CCC C399
HGNC 2309
MGI 104727
PubMed 17652102
RGD 70944
UniProt O14810
Wiki CPLX1

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. Complexin-1 binds to the SNAP receptor complex and disrupts it, allowing transmitter release. The highly specialized uptake and exocytosis system of synaptic vesicle traffic has been studied extensively as a model of membrane fusion. The fusion reaction begins with the assembly of a core complex consisting of the plasma membrane proteins syntaxin and SNAP25 and the synaptic vesicle protein synaptobrevin. The core complex then serves as a soluble NSF attachment protein receptor, or SNARE. Binding of SNAP to SNARE leads to ATP-dependent binding of NSF, which subsequently catalyzes disruption of the SNARE complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC399Hu01 Recombinant Complexin 1 (CPLX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC399Hu01 Polyclonal Antibody to Complexin 1 (CPLX1) WB
Assay Kits SEC399Hu ELISA Kit for Complexin 1 (CPLX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complexin 1 (CPLX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complexin 1 (CPLX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complexin 1 (CPLX1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC399Mu ELISA Kit for Complexin 1 (CPLX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complexin 1 (CPLX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complexin 1 (CPLX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complexin 1 (CPLX1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC399Ra ELISA Kit for Complexin 1 (CPLX1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. "Complexin cross-links prefusion SNAREs into a zigzag array."Nat. Struct. Mol. Biol. 18:927-933(2011) [PubMed] [Europe PMC] [Abstract]