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Carnitine Acetyltransferase (CRAT)

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CAT1; Carnitine O-Acetyltransferase; Carnitine acetylase

Carnitine Acetyltransferase (CRAT)
CCC C400
HGNC 2342
MGI 109501
PubMed 19912061
RGD 1303031
UniProt P43155
Wiki CRAT

Carnitine acetyltransferase (CRAT) is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments.

Different subcellular localizations of the CRAT mRNAs are thought to result from alternative splicing of the CRAT gene suggested by the divergent sequences in the 5' region of peroxisomal and mitochondrial CRAT cDNAs and the location of an intron where the sequences diverge. The alternatively splicing of this gene results in three distinct isoforms, one of which contains an N-terminial mitochondrial transit peptide, and has been shown to be located in mitochondria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC400Hu01 Recombinant Carnitine Acetyltransferase (CRAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC400Hu01 Polyclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
Assay Kits SEC400Hu ELISA Kit for Carnitine Acetyltransferase (CRAT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC400Mu01 Recombinant Carnitine Acetyltransferase (CRAT) Positive Control; Immunogen; SDS-PAGE; WB.
RPC400Mu02 Recombinant Carnitine Acetyltransferase (CRAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC400Mu01 Polyclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
PAC400Mu02 Polyclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
Assay Kits SEC400Mu ELISA Kit for Carnitine Acetyltransferase (CRAT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC400Ra01 Recombinant Carnitine Acetyltransferase (CRAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC400Ra01 Polyclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
MAC400Ra21 Monoclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
MAC400Ra22 Monoclonal Antibody to Carnitine Acetyltransferase (CRAT) WB; IHC; ICC; IP.
Assay Kits SEC400Ra ELISA Kit for Carnitine Acetyltransferase (CRAT) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations."Biochem. J. 303:37-41(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1."Genomics 23:94-99(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer."J. Biol. Chem. 278:13159-13165(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase."J. Struct. Biol. 146:416-424(2004) [PubMed] [Europe PMC] [Abstract]