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Cathepsin E (CTSE)

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CTS-E; CATE

Cathepsin E (CTSE)
CCC C410
HGNC 2530
MGI 107361
PubMed 23814481
RGD 2446
UniProt P14091
Wiki Cathepsin_E

Cathepsin E is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach.

It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC410Hu01 Recombinant Cathepsin E (CTSE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC410Hu01 Polyclonal Antibody to Cathepsin E (CTSE) WB; IHC; ICC; IP.
MAC410Hu22 Monoclonal Antibody to Cathepsin E (CTSE) WB; IHC; ICC; IP.
Assay Kits SEC410Hu ELISA Kit for Cathepsin E (CTSE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cathepsin E (CTSE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cathepsin E (CTSE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cathepsin E (CTSE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cathepsin E (CTSE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin E (CTSE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cathepsin E (CTSE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cathepsin E (CTSE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cathepsin E (CTSE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cathepsin E (CTSE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin E (CTSE) ELISA Kit Customized Service Offer
  1. "Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases."J. Biol. Chem. 264:16748-16753(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32."J. Biol. Chem. 267:1609-1614(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Subcellular localization and targeting of cathepsin E."J. Biol. Chem. 269:31259-31266(1994) [PubMed] [Europe PMC] [Abstract]
  4. "An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells."Biochim. Biophys. Acta 1625:203-206(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes."Arch. Biochem. Biophys. 304:352-358(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E."Biochem. Biophys. Res. Commun. 168:878-885(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Monomeric human cathepsin E."FEBS Lett. 366:72-74(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of cathepsin E expression during human B cell differentiation in vitro."Eur. J. Immunol. 26:1838-1843(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of human and mouse procathepsin E gene expression."Eur. J. Biochem. 268:2658-2668(2001) [PubMed] [Europe PMC] [Abstract]