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Cullin 1 (CUL1)

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Cullin 1 (CUL1)
CCC C412
HGNC 2551
MGI 1349658
PubMed 23535663
RGD 1308157
UniProt Q13616
Wiki CUL1

Cullin 1 is a protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC412Hu01 Recombinant Cullin 1 (CUL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC412Hu01 Polyclonal Antibody to Cullin 1 (CUL1) WB
Assay Kits n/a CLIA Kit for Cullin 1 (CUL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 1 (CUL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 1 (CUL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 1 (CUL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 1 (CUL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 1 (CUL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 1 (CUL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 1 (CUL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 1 (CUL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 1 (CUL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 1 (CUL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 1 (CUL1) ELISA Kit Customized Service Offer
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