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Calcitonin Receptor (CTR)

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CALCR; CRT; CT; CTR1

Calcitonin Receptor (CTR)
CCC C413
HGNC 1440
MGI 101950
PubMed 21649645
UniProt P30988
Wiki CTR

The calcitonin receptor (CT) is a G protein-coupled receptor which binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism .CT works by activating the G-proteins Gs and Gq, The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT+RAMP1), AMY2 (CT+RAMP2), and AMY3 (CT+RAMP3). A cell line had been shown to respond to calcitonin (CT, or CALCA) with increases in content of cellular cAMP. Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon and human calcitonin. The expressed CALCR was coupled to adenylate cyclase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcitonin Receptor (CTR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcitonin Receptor (CTR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcitonin Receptor (CTR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcitonin Receptor (CTR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcitonin Receptor (CTR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC413Mu01 Recombinant Calcitonin Receptor (CTR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC413Mu01 Polyclonal Antibody to Calcitonin Receptor (CTR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcitonin Receptor (CTR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcitonin Receptor (CTR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC413Ra01 Recombinant Calcitonin Receptor (CTR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC413Ra01 Polyclonal Antibody to Calcitonin Receptor (CTR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcitonin Receptor (CTR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcitonin Receptor (CTR) ELISA Kit Customized Service Offer
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  2. "Cloning and characterization of an abundant subtype of the human calcitonin receptor."Mol. Pharmacol. 46:246-255(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene."Endocrinology 136:5377-5384(1995) [PubMed] [Europe PMC] [Abstract]
  4. "An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid."FEBS Lett. 342:214-216(1994) [PubMed] [Europe PMC] [Abstract]
  5. "A novel calcitonin receptor gene in human osteoclasts from normal bone marrow."FEBS Lett. 458:409-414(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular characterization of two novel isoforms of the human calcitonin receptor."Gene 343:143-151(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor."Endocrinology 136:2047-2051(1995) [PubMed] [Europe PMC] [Abstract]
  13. "A new type of human calcitonin receptor isoform generated by alternative splicing."Biochem. Biophys. Res. Commun. 209:744-751(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple promoters regulate human calcitonin receptor gene expression."Biochem. Biophys. Res. Commun. 272:738-743(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women."Biochem. Biophys. Res. Commun. 248:190-195(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function."Br. J. Pharmacol. 168:644-657(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women."Biochem. Biophys. Res. Commun. 245:622-626(1998) [PubMed] [Europe PMC] [Abstract]
  19. "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women."Hum. Mol. Genet. 7:2129-2133(1998) [PubMed] [Europe PMC] [Abstract]