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Docking Protein 1 (DOK1)

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P62DOK; Downstream Of Tyrosine Kinase 1

Docking Protein 1 (DOK1)
CCC C434
HGNC 2990
MGI 893587
PubMed 21690289
RGD 1309499
UniProt Q99704
Wiki DOK1

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML.

Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC434Hu01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Docking Protein 1 (DOK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Docking Protein 1 (DOK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Docking Protein 1 (DOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 1 (DOK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Docking Protein 1 (DOK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Docking Protein 1 (DOK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Docking Protein 1 (DOK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Docking Protein 1 (DOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 1 (DOK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC434Ra01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC434Ra01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Docking Protein 1 (DOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Docking Protein 1 (DOK1) ELISA Kit Customized Service Offer
  1. "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells."Cell 88:197-204(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a truncated p62Dok1 isoform, p22Dokdel."Eur. J. Immunogenet. 27:145-148(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt."J. Biol. Chem. 276:42843-42850(2001) [PubMed] [Europe PMC] [Abstract]
  6. "DOK4 and DOK5: new Dok-related genes expressed in human T cells."Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation."FEBS Lett. 583:2441-2445(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1."FEBS J. 280:4539-4559(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding."J. Biol. Chem. 283:5420-5426(2008) [PubMed] [Europe PMC] [Abstract]