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Diacylglycerol Kinase Alpha (DGKa)

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DGK-A; DAGK; DAGK1; DGK-alpha; 80 kDa diacylglycerol kinase; Diglyceride kinase alpha

Diacylglycerol Kinase Alpha (DGKa)
CCC C435
HGNC 2849
MGI 102952
PubMed 12923107
RGD 70904
UniProt P23743
Wiki DGKA

Diacylglycerol kinase alpha is an enzyme belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.Diacylglycerol (DAG) functions in intracellular signaling pathways as an allosteric activator of protein kinase C (PKC). In addition, DAG appears to play a role in regulating RAS and RHO family proteins by activating the guanine nucleotide exchange factors VAV and RASGRP1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diacylglycerol Kinase Alpha (DGKa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) Polyclonal Antibody Customized Service Offer
Assay Kits SEC435Hu ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC435Mu01 Recombinant Diacylglycerol Kinase Alpha (DGKa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC435Mu01 Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) WB; IHC; ICC; IP.
Assay Kits SEC435Mu ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC435Ra01 Recombinant Diacylglycerol Kinase Alpha (DGKa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC435Ra01 Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) ELISA Kit Customized Service Offer
  1. "Purification, cDNA-cloning and expression of human diacylglycerol kinase."FEBS Lett. 275:151-158(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12."Mamm. Genome 5:123-124(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis."Genomics 22:246-247(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "NMR structure of diacylglycerol kinase alpha, NESGC target HR532."Submitted (JAN-2005) to the PDB data bank