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Dipeptidase 1, Renal (DPEP1)

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RDP; MBD1; MDP; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase

Dipeptidase 1, Renal (DPEP1)
CCC C441
HGNC 3002
MGI 94917
PubMed 22363658
RGD 620324
UniProt P16444
Wiki Dipeptidase_1

DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982).

DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC441Hu01 Recombinant Dipeptidase 1, Renal (DPEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC441Hu01 Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB; IHC; ICC; IP.
MAC441Hu21 Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB
MAC441Hu22 Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB
Assay Kits SEC441Hu ELISA Kit for Dipeptidase 1, Renal (DPEP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dipeptidase 1, Renal (DPEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dipeptidase 1, Renal (DPEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dipeptidase 1, Renal (DPEP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dipeptidase 1, Renal (DPEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dipeptidase 1, Renal (DPEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dipeptidase 1, Renal (DPEP1) ELISA Kit Customized Service Offer
  1. "Cloning and structural analysis of genomic DNA for human renal dipeptidase."Biochim. Biophys. Acta 1172:181-183(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human microsomal dipeptidase deduced from molecular cloning."J. Biol. Chem. 265:3992-3995(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structural analysis and expression of human renal dipeptidase."Biotechnol. Prog. 10:134-140(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme."Biochem. J. 265:429-433(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of human microsomal dipeptidase."J. Biochem. 105:957-961(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form."J. Biol. Chem. 265:15341-15345(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Importance of Glu-125 in the catalytic activity of human renal dipeptidase."Biochim. Biophys. Acta 1163:42-48(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis."J. Mol. Biol. 321:177-184(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]