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Doublecortin (DCX)

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DBCN; DC; LISX; SCLH; XLIS; Doublin; Doublecortex; Lissencephalin-X; Lissencephaly,X-Linked; Neuronal migration protein doublecortin

Doublecortin (DCX)
CCC C442
HGNC 2714
MGI 1277171
PubMed 10399933
RGD 620670
UniProt O43602
Wiki Doublecortin

Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, and occurs at the same time that these cells begin to express, a marker for mature neurons.
Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise, which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC442Hu01 Recombinant Doublecortin (DCX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC442Hu01 Polyclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
MAC442Hu22 Monoclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
Assay Kits SEC442Hu ELISA Kit for Doublecortin (DCX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC442Mu01 Recombinant Doublecortin (DCX) Positive Control; Immunogen; SDS-PAGE; WB.
RPC442Mu02 Recombinant Doublecortin (DCX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC442Mu01 Polyclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
PAC442Mu02 Polyclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
Assay Kits SEC442Mu ELISA Kit for Doublecortin (DCX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC442Ra01 Recombinant Doublecortin (DCX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC442Ra01 Polyclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
MAC442Ra21 Monoclonal Antibody to Doublecortin (DCX) WB; IHC; ICC; IP.
Assay Kits SEC442Ra ELISA Kit for Doublecortin (DCX) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome."Cell 92:51-61(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein."Cell 92:63-72(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology."Cytoskeleton 69:514-527(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth."Am. J. Hum. Genet. 94:470-478(2014) [PubMed] [Europe PMC] [Abstract]
  8. "The DCX-domain tandems of doublecortin and doublecortin-like kinase."Nat. Struct. Biol. 10:324-333(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects."Hum. Mol. Genet. 7:1327-1332(1998) [PubMed] [Europe PMC] [Abstract]
  10. "LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation."Hum. Mol. Genet. 7:2029-2037(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH)."Hum. Mol. Genet. 7:1063-1070(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of mutations in the gene doublecortin in patients with double cortex syndrome." Ann. Neurol. 45:146-153(1999) [PubMed] [Europe PMC] [Abstract]
  13. "A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia."Hum. Genet. 104:341-344(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1."Hum. Mol. Genet. 8:1757-1760(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic alteration of the DCX gene in Japanese patients with subcortical laminar heterotopia or isolated lissencephaly sequence."J. Hum. Genet. 45:167-170(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation of the doublecortin gene in male patients with double cortex syndrome: somatic mosaicism detected by hair root analysis."Ann. Neurol. 50:547-551(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Mutation analysis of the DCX gene and genotype/phenotype correlation in subcortical band heterotopia."Eur. J. Hum. Genet. 9:5-12(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Incomplete penetrance with normal MRI in a woman with germline mutation of the DCX gene."Neurology 57:327-330(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females." Brain 125:2507-2522(2002) [PubMed] [Europe PMC] [Abstract]
  20. "So-called 'cryptogenic' partial seizures resulting from a subtle cortical dysgenesis due to a doublecortin gene mutation."Seizure 11:273-277(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Somatic mosaicism and variable penetrance in doublecortin-associated migration disorders."Neurology 60:329-332(2003) [PubMed] [Europe PMC] [Abstract]