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Dystrobrevin Binding Protein 1 (DTNBP1)

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DBND; HPS7; My031; SDY; Dysbindin; Biogenesis of lysosome-related organelles complex 1 subunit 8; Hermansky-Pudlak syndrome 7 protein

Dystrobrevin Binding Protein 1 (DTNBP1)
CCC C444
HGNC 17328
MGI 2137586
PubMed 19449336
UniProt Q96EV8
Wiki Dysbindin

Dysbindin is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin. In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus.Probable dysbindin-related mechanisms causing brain dysfunction are not fully known, but in one study, schizophrenic patients carrying the high-risk haplotype demonstrated visual processing deficits. In another work, damping down the DTNBP1 expression led to an increase in cell surface dopamine D2-receptor levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC444Hu01 Recombinant Dystrobrevin Binding Protein 1 (DTNBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC444Mu01 Recombinant Dystrobrevin Binding Protein 1 (DTNBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC444Mu01 Polyclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC444Ra01 Recombinant Dystrobrevin Binding Protein 1 (DTNBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC444Ra01 Polyclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrobrevin Binding Protein 1 (DTNBP1) ELISA Kit Customized Service Offer
  1. "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)."Nat. Genet. 35:84-89(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia."Hum. Mol. Genet. 13:2699-2708(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia."J. Clin. Invest. 113:1353-1363(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin."Hum. Mol. Genet. 15:3041-3054(2006) [PubMed] [Europe PMC] [Abstract]
  9. "BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes."Mol. Biol. Cell 17:4027-4038(2006) [PubMed] [Europe PMC] [Abstract]
  10. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization."J. Neurosci. 27:12390-12395(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression."Hum. Mol. Genet. 18:3851-3863(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia."(In) Javitt D.C., Kantrowitz J. (eds.);Handbook of neurochemistry and molecular neurobiology (3rd ed.), pp.27:107-241, Springer Science, New York (2009)
  16. "Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization."Biochem. Biophys. Res. Commun. 379:191-195(2009) [PubMed] [Europe PMC] [Abstract]
  17. "TRIM32 is an E3 ubiquitin ligase for dysbindin."Hum. Mol. Genet. 18:2344-2358(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Direct interaction of dysbindin with the AP-3 complex via its mu subunit."Neurochem. Int. 54:431-438(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner."PLoS ONE 4:E4199-E4199(2009) [PubMed] [Europe PMC] [Abstract]
  20. "DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias."Genes Brain Behav. 9:489-497(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression."J. Biol. Chem. 285:38630-38640(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location."PLoS ONE 6:E16886-E16886(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]