≡

Fatty Acid Desaturase 1 (FADS1)

[Edit]

D5D; FADS6; FADSD5; LLCDL1; TU12; Delta-5 Desaturase; Delta(5) fatty acid desaturase

Fatty Acid Desaturase 1 (FADS1)
CCC C468
HGNC 3574
MGI 1923517
PubMed 23396965
RGD 621678
UniProt O60427
Wiki FADS1

Fatty acid desaturase 1 is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain.

FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC468Hu01 Recombinant Fatty Acid Desaturase 1 (FADS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC468Hu01 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
MAC468Hu22 Monoclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
Assay Kits SEC468Hu ELISA Kit for Fatty Acid Desaturase 1 (FADS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPC468Mu21 OVA Conjugated Fatty Acid Desaturase 1 (FADS1) Immunogen; SDS-PAGE; WB.
Antibodies PAC468Mu08 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
PAC468Mu01 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fatty Acid Desaturase 1 (FADS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fatty Acid Desaturase 1 (FADS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC468Ra01 Recombinant Fatty Acid Desaturase 1 (FADS1) Positive Control; Immunogen; SDS-PAGE; WB.
CPC468Ra21 OVA Conjugated Fatty Acid Desaturase 1 (FADS1) Immunogen; SDS-PAGE; WB.
Antibodies PAC468Ra01 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
MAC468Ra21 Monoclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
PAC468Ra08 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
PAC468Mi08 Polyclonal Antibody to Fatty Acid Desaturase 1 (FADS1) WB; IHC; ICC; IP.
Assay Kits SEC468Ra ELISA Kit for Fatty Acid Desaturase 1 (FADS1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase."J. Biol. Chem. 274:37335-37339(1999) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid."Biochem. J. 347:719-724(2000) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family."Genomics 66:175-183(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids."J. Lipid Res. 53:1502-1512(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]