Flavin Containing Monooxygenase 2, Non Functional (FMO2)
[Edit]FMO1B1; Dimethylaniline oxidase 2; Pulmonary flavin-containing monooxygenase 2; Dimethylaniline monooxygenase [N-oxide-forming] 2
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The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded.
Dimethylaniline monooxygenase [N-oxide-forming] 2 represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC482Hu01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC482Hu01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC482Mu01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC482Mu01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC482Ra01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC482Ra01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | ELISA Kit Customized Service Offer |
- "The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein."J. Biol. Chem. 273:30599-30607(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans."Toxicol. Appl. Pharmacol. 168:216-224(2000) [PubMed] [Europe PMC] [Abstract]
- "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
- "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
- "The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa."Pharmacogenet. Genomics 18:877-886(2008) [PubMed] [Europe PMC] [Abstract]