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Ferroportin (FPN)

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SLC40A1; FPN1; HFE4; IREG1; MTP1; SLC11A3; Solute Carrier Family 40,Member 1; Iron-Regulated Transporter

Ferroportin (FPN)
CCC C489
HGNC 10909
MGI 1315204
PubMed 16054057
UniProt Q9NP59
Wiki Ferroportin

Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. Recent research suggests that ferroportin is inhibited by hepcidin, which therefore is the "master regulator" of human iron metabolism. Hepcidin binds to ferroportin, and results in the internalisation of ferroportin within the cell, followed by degradation by the proteasome. This results in retention of iron within the cell, and a reduction in iron levels within the plasma. This is part of the mechanism that causes anaemia of chronic disease; hepcidin is released from the liver in response to inflammatory cytokines, namely interleukin-6, which results in an increased hepcidin concentration and a consequent decrease in plasma iron levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Hu01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC489Hu01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Hu22 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
LAC489Hu71 Biotin-Linked Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC.
MAC489Hu21 Monoclonal Antibody to Ferroportin (FPN) WB
MAC489Hu24 Monoclonal Antibody to Ferroportin (FPN) WB
MAC489Hu26 Monoclonal Antibody to Ferroportin (FPN) WB
LAC489Hu76 Biotin-Linked Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC.
Assay Kits SEC489Hu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEC489Hu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Mu01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC489Mu02 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
CPC489Mu21 OVA Conjugated Ferroportin (FPN) Immunogen; SDS-PAGE; WB.
Antibodies PAC489Mu01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
PAC489Mu02 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
PAC489Mi01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
Assay Kits SEC489Mu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC489Mu CLIA Kit for Ferroportin (FPN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Ra01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
CPC489Ra21 OVA Conjugated Ferroportin (FPN) Immunogen; SDS-PAGE; WB.
Antibodies PAC489Ra01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Ra21 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
PAC489Mi01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
Assay Kits SEC489Ra ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter."Nature 403:776-781(2000) [PubMed] [Europe PMC] [Abstract]
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  9. "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene."J. Clin. Invest. 108:619-623(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis."Nat. Genet. 28:213-214(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis."Blood 100:692-694(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)."Blood 100:695-697(2002) [PubMed] [Europe PMC] [Abstract]
  14. "A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4."Blood 100:733-734(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3)."Br. J. Haematol. 119:539-546(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (SLC11A3) mutations."Blood 102:1904-1910(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene."Blood Cells Mol. Dis. 31:299-304(2003) [PubMed] [Europe PMC] [Abstract]
  18. "A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient."Gut 52:1215-1217(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family."Haematologica 88:824-826(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload."J. Hepatol. 39:286-289(2003) [PubMed] [Europe PMC] [Abstract]
  21. "The ferroportin disease."Blood Cells Mol. Dis. 32:131-138(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Recent advances in understanding haemochromatosis: a transition state."J. Med. Genet. 41:721-730(2004) [PubMed] [Europe PMC] [Abstract]
  23. ErratumJ. Med. Genet. 41:959-959(2004)
  24. "Genetic and clinical heterogeneity of ferroportin disease."Br. J. Haematol. 131:663-670(2005) [PubMed] [Europe PMC] [Abstract]
  25. ErratumBr. J. Haematol. 132:806-806(2006)