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G-Elongation Factor, Mitochondrial 1 (GFM1)

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COXPD1; EFG; EFG1; EFGM; EGF1; GFM; hEFG1

G-Elongation Factor, Mitochondrial 1 (GFM1)
CCC C497
HGNC 13780
MGI 107339
PubMed 21986555
RGD 631396
UniProt Q96RP9
Wiki GFM1

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.

Elongation factor G 1, mitochondrial is one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC497Hu01 Recombinant G-Elongation Factor, Mitochondrial 1 (GFM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC497Hu01 Polyclonal Antibody to G-Elongation Factor, Mitochondrial 1 (GFM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC497Mu01 Recombinant G-Elongation Factor, Mitochondrial 1 (GFM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC497Mu01 Polyclonal Antibody to G-Elongation Factor, Mitochondrial 1 (GFM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G-Elongation Factor, Mitochondrial 1 (GFM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G-Elongation Factor, Mitochondrial 1 (GFM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G-Elongation Factor, Mitochondrial 1 (GFM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Elongation Factor, Mitochondrial 1 (GFM1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and gfm, and mapping of GFM to human chromosome 3q25.1-q26.2."Genomics 74:109-114(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution."Hum. Genet. 109:542-550(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and characterization of isoform 1 of human mitochondrial elongation factor G."Protein Expr. Purif. 37:368-376(2004) [PubMed] [Europe PMC] [Abstract]
  7. "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis."Mol. Cell 35:502-510(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency."N. Engl. J. Med. 351:2080-2086(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu."Am. J. Hum. Genet. 80:44-58(2007) [PubMed] [Europe PMC] [Abstract]